The infusion process

PERJETA is given every 3 weeks as an IV infusion

PERJETA is given as an intravenous (IV) infusion, which means that medication is administered directly and slowly into the bloodstream through a vein.

When you begin treatment, your doctor will start PERJETA, Herceptin® (trastuzumab), and docetaxel at the same time, and may adjust the medicines in your treatment plan over time.

If your doctor stops your docetaxel, you may still take PERJETA and Herceptin. If your doctor delays or stops Herceptin treatment, then PERJETA should also be delayed or stopped.

How long does each infusion last?

Infusion times may vary from person to person depending on tolerability.

After each medication is given, your doctor or nurse will wait 30 to 60 minutes to check for any reactions. If a reaction occurs, they may adjust, delay, or stop treatment.

During your first treatment

The medicines are given more slowly during your first visit. Your first dose of PERJETA will be given as an infusion over 60 minutes. Herceptin will be given over 90 minutes, and docetaxel over 60 minutes.

How long will you stay on therapy?

Docetaxel is given for a minimum of 6 cycles. If your doctor stops docetaxel (for example, due to side effects), you can continue receiving PERJETA and Herceptin. You can stay on PERJETA and Herceptin until your disease is no longer controlled or your side effects require you to stop treatment.

If you doctor delays or stops your Herceptin treatment, then PERJETA should also be delayed or stopped.

Side effects may occur with PERJETA

PERJETA is given together with Herceptin and docetaxel, and side effects may occur.

What are the most serious side effects of PERJETA?

PERJETA may cause heart problems, including those without symptoms (such as reduced heart function) and those with symptoms (such as congestive heart failure).

Receiving PERJETA during pregnancy can result in the death of an unborn baby and birth defects.

Other possible serious and sometimes fatal side effects of PERJETA therapy include:

  • Infusion-related reactions
  • Severe allergic reactions (hypersensitivity reactions/anaphylaxis)

The most common side effects of PERJETA when given with Herceptin and docetaxel for treatment of breast cancer that has spread to other parts of the body (metastatic) are diarrhea, hair loss, low levels of white blood cells with or without fever, nausea, feeling tired, rash, and damage to the nerves (numbness, tingling, pain in hands/feet).

Side effects may vary based on chemotherapy regimen.

Talk to your doctor about any side effects you experience. Here are some tips you can try.

Remember, the tips mentioned below may not work for everyone. Be sure to talk with your doctor or other healthcare provider before trying any of these tips.

Select side effects associated with PERJETA + Herceptin + docetaxel during metastatic breast cancer treatment


Hair loss

Nausea and vomiting

Feeling tired


Be aware that these are not all of the side effects associated with PERJETA. For more information, please review the PERJETA Important Safety Information and the full Prescribing Information.

You are encouraged to report side effects to Genentech and the FDA. You may contact Genentech by calling 1-888-835-2555. You may contact the FDA by visiting or calling 1-800-FDA-1088.

Enroll in a free patient support program designed specifically for people living with HER2+ breast cancer. 

Discover information and resources to help you have an informative conversation with your doctor.