Early HER2+ Breast Cancer | PERJETA® (pertuzumab)

What should I know about side effects with PERJETA?

Not all people have serious side effects; however, side effects with PERJETA therapy are common. It is important to know what side effects may happen and what symptoms you should watch for
Your doctor may stop treatment if serious side effects happen. Be sure to contact your healthcare team right away if you have questions or are worried about any side effects

What are the most serious side effects of PERJETA?

PERJETA may cause heart problems, including those without symptoms (such as reduced heart function) and those with symptoms (such as congestive heart failure).

Your doctor may run tests to monitor your heart function before and during treatment with PERJETA
Based on test results, your doctor may hold or discontinue treatment with PERJETA
Contact a health care professional immediately for any of the following: new onset or worsening shortness of breath, cough, swelling of the ankles/legs, swelling of the face, palpitations, weight gain of more than 5 pounds in 24 hours, dizziness or loss of consciousness

Receiving PERJETA during pregnancy can result in the death of an unborn baby and birth defects.

Birth control should be used while receiving PERJETA and for 7 months after your last dose of PERJETA. If you are a mother who is breastfeeding, you should talk with your doctor about either stopping breastfeeding or stopping PERJETA
If you think you may be pregnant, you should contact your healthcare provider immediately
If you are exposed to PERJETA during pregnancy, or become pregnant while receiving PERJETA or within 7 months following the last dose of PERJETA in combination with Herceptin, you are encouraged to enroll in the MotHER Pregnancy Registry by contacting 1‑800-690-6720 or visiting http://www.motherpregnancyregistry.com/ and report PERJETA exposure to Genentech at 1-888-835-2555

What are other possible serious side effects?

PERJETA should not be used in patients who are allergic to pertuzumab or to any of the ingredients in PERJETA

Infusion-related reactions: PERJETA is a medicine that is delivered into a vein through a needle. PERJETA has been associated with infusion-related reactions, some fatal. The most common infusion-related reactions when receiving PERJETA, Herceptin, and docetaxel were feeling tired, abnormal or altered taste, allergic reactions, muscle pain, and vomiting. The most common infusion-related reactions when receiving PERJETA alone were fever, chills, feeling tired, headache, weakness, allergic reactions, and vomiting

Severe allergic reactions: Some people receiving PERJETA may have severe allergic reactions, called hypersensitivity reactions or anaphylaxis, which may happen quickly and may affect many areas of the body. Severe allergic reactions, some fatal, have been observed in patients treated with PERJETA

What are the most common side effects?

The most common side effects of PERJETA when given with Herceptin and docetaxel for treatment of breast cancer that has spread to other parts of the body (metastatic) are:

Diarrhea
Hair loss
Low levels of white blood cells with or without fever
Nausea
Feeling tired
Rash
Damage to the nerves (numbness, tingling, pain in hands/feet)

The most common side effects of PERJETA when given with Herceptin and chemotherapy as part of an early breast cancer regimen before surgery are:

Constipation
Damage to the nerves (numbness, tingling, pain in hands/feet)
Diarrhea
Feeling tired
Hair loss
Headache
Low levels of red blood cells
Low levels of white blood cells with or without fever
Low platelet count
Mouth blisters or sores
Nausea
Pain in the muscles
Vomiting
Weakness

Side effects may vary based on chemotherapy regimen.

The most common side effects of PERJETA when given with Herceptin and chemotherapy as part of an early breast cancer regimen after surgery are:

Diarrhea
Nausea
Hair Loss
Feeling tired
Damage to the nerves (numbness, tingling, pain in hands/feet)
Vomiting

You are encouraged to report side effects to Genentech and the FDA. You may report side effects to the FDA at 1‑800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1‑888-835-2555.

Please see full Prescribing Information for additional Important Safety Information, including most serious side effects.

PERJETA FOR HER2+ EARLY BREAST CANCER

Learn about PERJETA-based treatment before surgery

PERJETA is part of an FDA-approved neoadjuvant treatment regimen for HER2+ early breast cancer, along with Herceptin^® (trastuzumab) and chemotherapy. Talk to your doctor to determine if treatment before breast cancer surgery may be right for you.

Important Safety Information/Indication

What does PERJETA treat?

What should I know about side effects with PERJETA?

What are the most serious side effects of PERJETA?

What are other possible serious side effects?

What are the most common side effects?

PERJETA FOR HER2+ EARLY BREAST CANCER

Learn about PERJETA-based treatment before surgery

PERJETA is part of an FDA-approved neoadjuvant treatment regimen for HER2+ early breast cancer, along with Herceptin® (trastuzumab) and chemotherapy. Talk to your doctor to determine if treatment before breast cancer surgery may be right for you.

Important Safety Information/Indication

What does PERJETA treat?

What should I know about side effects with PERJETA?

What are the most serious side effects of PERJETA?

What are other possible serious side effects?

What are the most common side effects?

Coming Soon

PERJETA is part of an FDA-approved neoadjuvant treatment regimen for HER2+ early breast cancer, along with Herceptin^® (trastuzumab) and chemotherapy. Talk to your doctor to determine if treatment before breast cancer surgery may be right for you.