As seen in preclinical models: PERJETA targets a different subdomain on the HER2 receptor than Herceptin does. When used together, PERJETA and Herceptin® (trastuzumab) provide a dual blockade of HER2-driven signaling pathways.1-3
PERJETA binds to subdomain II of HER2 receptors and blocks its ligand-dependent hetrodimerization with HER1, HER3, and HER4.1
PERJETA inhibits HER2:HER3 dimer formation and downstream signaling, suppressing HER2-mediated cell proliferation. It also augments antibody-dependent cell-mediated cytotoxicity (ADCC).1,8-10
Herceptin binds to subdomain IV and disrupts ligand-independent HER2 signaling. Herceptin also mediates ADCC.2,3
PERJETA and Herceptin together provide a dual blockade of HER2-driven signaling pathways.1,2
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